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AdipoGen Antipain dihydrochloride

Chemical. CAS 37682-72-7. Formula C27H44N10O6 . 2HCl. MW 604.7 . 72.9. Synthetic. Potent reversible inhibitor of serine/cysteine proteases and some trypsin-like proteases. Inhibits papain, trypsin and trypsin-like serine proteases as well as cathepsin A, B and D. Similar activity spectrum comparable to leupeptin AG-CP3-7000. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase. Inhibits transformation of NIH3T3 cells after transfection with an activated H-ras oncogene. Used to evaluate the role of proteases in the process of malignant cell transformations. Shows antibacterial and antiparasitic activity.
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