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  8. APY 29, Tocris Bioscience™

APY 29, Tocris Bioscience™

Catalog No. p-4815633 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity

Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.

Chemical Identifiers

CAS 1216665-49-4
Molecular Formula C17H16N8
Molecular Weight (g/mol) 332.371
InChI Key WJNBSTLIALIIEW-UHFFFAOYSA-N
Synonym apy29, apy 29, apy-29, n2-1h-benzimidazol-6-yl-n4-5-cyclopropyl-1h-pyrazol-3-yl-2,4-pyrimidinediamine, n2-1h-benzo d imidazol-6-yl-n4-5-cyclopropyl-1h-pyrazol-3-yl pyrimidine-2,4-diamine, n∼2∼-1h-benzimidazol-5-yl-n∼4∼-3-cyclopropyl-1h-pyrazol-5-yl pyrimidine-2,4-diamine, apy 29;apy-29, 2-n-1h-1,3-benzodiazol-5-yl-4-n-5-cyclopropyl-2h-pyrazol-3-yl pyrimidine-2,4-diamine, 2-n-3h-benzimidazol-5-yl-4-n-5-cyclopropyl-1h-pyrazol-3-yl pyrimidine-2,4-diamine, n2-3h-1,3-benzodiazol-5-yl-n4-5-cyclopropyl-1h-pyrazol-3-yl pyrimidine-2,4-diamine
PubChem CID 42627755
IUPAC Name 2-N-(3H-benzimidazol-5-yl)-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
SMILES C1CC1C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CN5

Specifications

Color White
Quantity 10 mg
Formula Weight 332.36
Percent Purity >98%
Physical Form Solid
Chemical Name or Material APY 29

Safety and Handling

Recommended Storage Store at -20°C
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