Ascomycin, 95%, Thermo Scientific Chemicals

Description

Internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus.

Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution™ is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution™ is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

Solubility
Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Specifications

Chemical Identifiers

• CAS: 104987-12-4
• Molecular Formula: C43H69NO12
• Molecular Weight (g/mol): 792.02
• MDL Number: MFCD06198665
• InChI Key: ZDQSOHOQTUFQEM-NURRSENYSA-N
• Synonym: ascomycin, immunomycin, unii-auf4u5nsjk, ascomycin fk520, auf4u5nsjk, chembl8597, 15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetram, ascomycin from streptomyces hygroscopicus var. ascomyceticus, 15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-8-ethyl-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetramethyl-, 3s-3r* e 1s*,3s*,4s* ,4s*,19s*,26ar*, ascomycin fk 520, fr 900520, imm
• PubChem CID: 5282071
• ChEBI: CHEBI:29582
• SMILES: CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C

• Melting Point: 156°C to 160°C
• Color: White
• Boiling Point: 868°C
• Flash Point: >110°C (230°F)
• Quantity: 25 mg
• Solubility Information: Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming; Very poorly soluble in water
• Formula Weight: 790
• Percent Purity: 95%
• Physical Form: Powder
• Chemical Name or Material: Ascomycin

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement H302-H312-H332 Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statement	GHS P Statement P261-P280-P304+P340-P301+P312-P312-P501a Avoid breathing dust/fume/gas/mist/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Call a POISON CENTER or doctor/physician if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations.
RTECSNumber	KD4185000
TSCA	No
storageNote1	−30° to −10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only