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Astemizole, Tocris Bioscience™

Catalog No. 348950 Shop All R&D Systems Products
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Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker

Orally active, potent histamine H1 antagonist (IC50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM). Also potent KV11.1 (hERG) channel blocker (IC50 = 0.9 nM) that displays cardiotoxicity in vivo.

Chemical Identifiers

CAS

68844-77-9

Molecular Formula

C28H31FN4O

Molecular Weight (g/mol)

458.581

InChI Key

GXDALQBWZGODGZ-UHFFFAOYSA-N

Synonym

astemizole, hismanal, histaminos, paralergin, laridal, retolen, alermizol, astemison, astemizol, histamen

PubChem CID

2247

ChEBI

CHEBI:2896

IUPAC Name

1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine

SMILES

COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

Specifications

Quantity

50 mg

Formula Weight

458.57

Percent Purity

>99%

Chemical Name or Material

Astemizole

Recommended Storage

Store at +4°C
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