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Axitinib, Tocris Bioscience™

Catalog No. p-4816546 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent VEGFR-1, -2 and -3 inhibitor

Axitinib is a potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Axitinib exhibits minimal activity against a panel of ∼100 protein kinases. Axitinib inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Axitinib blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib (10 mg/kg) decreases T-cell exhaustion and tumor and T-cell hypoxia and improves survival in mice in vivo. Orally available.

Chemical Identifiers

CAS 319460-85-0
Molecular Formula C22H18N4OS
Molecular Weight (g/mol) 386.473
InChI Key RITAVMQDGBJQJZ-FMIVXFBMSA-N
Synonym axitinib, inlyta, axitinibum, unii-c9lvq0yuxg, e-n-methyl-2-3-2-pyridin-2-yl vinyl-1h-indazol-6-yl thio benzamide, c9lvq0yuxg, n-methyl-2-3-1e-2-pyridin-2-yl ethenyl-1h-indazol-6-yl sulfanyl benzamide, n-methyl-2-3-e-2-pyridin-2-yl ethenyl-1h-indazol-6-yl sulfanyl benzamide, e-n-methyl-2-3-2-pyridin-2-yl vinyl-1h-indazol-6-ylthio benzamide, dsstox_cid_28975
PubChem CID 6450551
ChEBI CHEBI:66910
IUPAC Name N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
SMILES CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4

Specifications

Quantity 10 mg
Formula Weight 386.47
Percent Purity >99%
Chemical Name or Material Axitinib

Safety and Handling

Recommended Storage Store at +4°C
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