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  8. AZ 11645373, Tocris Bioscience™

AZ 11645373, Tocris Bioscience™

Catalog No. p-4783768 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent and selective human P2X7 antagonist

Potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (KB values are 15 and 92 nM respectively).

Chemical Identifiers

CAS 227088-94-0
Molecular Formula C24H21N3O5S
Molecular Weight (g/mol) 463.51
MDL Number MFCD11045276
InChI Key VQEHBLGYANQWEA-UHFFFAOYNA-N
Synonym 3-1-3'-nitro 1,1'-biphenyl-4-yl oxy methyl-3-4-pyridinyl propyl-2,4-thiazolidinedione, d02efx, 2,4-thiazolidinedione, 3-1-3'-nitro 1,1'-biphenyl-4-yl oxy methyl-3-4-pyridinyl propyl, 3-1-4-3-nitrophenyl phenoxy-4-pyridin-4-yl butan-2-yl-1,3-thiazolidine-2,4-dione, 3-1-3'-nitro-1,1'-biphenyl-4-yl oxy-4-pyridin-4-yl butan-2-yl-1,3-thiazolidine-2,4-dione, 3-1-3-nitro 1,1-biphenyl-4-yl oxy methyl-3-4-pyridinyl propyl-2,4-thiazolidinedione
PubChem CID 9804433
IUPAC Name 3-[1-({3'-nitro-[1,1'-biphenyl]-4-yl}oxy)-4-(pyridin-4-yl)butan-2-yl]-1,3-thiazolidine-2,4-dione
SMILES [O-][N+](=O)C1=CC=CC(=C1)C1=CC=C(OCC(CCC2=CC=NC=C2)N2C(=O)CSC2=O)C=C1

Specifications

Quantity 10 mg
Formula Weight 463.51
Percent Purity >98%
Chemical Name or Material AZ 11645373

Safety and Handling

Recommended Storage Store at +4°C
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