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Benzenesulfonamide, 98+%, Thermo Scientific Chemicals
Biospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. Benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
The presence of the benzenesulfonylamido (BS) groups shifted the activity of classic antimicrobial fluoroquinolones from being more active against Gram-negative to Gram-positive strains. Biospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. In engineering the specificity of antibacterial fluoroquinolones, benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.
Solubility
Soluble in methanol (25 mg/ml), and water (4.3 mg/ml at 16°C).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Specifications
Melting Point
151°C to 154°C
Flash Point
250°C (482°F)
Odor
Odorless
Quantity
250 g
Beilstein
1100566
Solubility Information
Soluble in methanol (25mg/ml),and water (4.3mg/ml at 16°C).
Formula Weight
157.19
Percent Purity
≥98%
Chemical Name or Material
Benzenesulfonamide
Hazard Category
H302
Hazard Statement
GHS H Statement
H302
Harmful if swallowed.
Precautionary Statement
P264b-P270-P301+P312-P330-P501c
EINECSNumber
202-637-1
RTECSNumber
DA9380000
TSCA
Yes
Recommended Storage
Ambient temperatures
RUO – Research Use Only
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