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Berberine chloride, Thermo Scientific Chemicals
Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.
Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
Specifications
Color
Yellow to Orange
Quantity
5 g
Beilstein
3836585
Solubility Information
Soluble in dimethyl sulfoxide (74mg/ml at 25°C),ethanol (<1mg/ml at 25°C),water (<1mg/ml at 25°C),and methanol.
Formula Weight
371.82
Physical Form
Powder
Chemical Name or Material
Berberine chloride
EINECSNumber
211-195-9
TSCA
Yes
Recommended Storage
Keep cold
RUO – Research Use Only
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