Berberine chloride, Thermo Scientific Chemicals

Description

 

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.

Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Specifications

Chemical Identifiers

• CAS: 633-65-8
• Molecular Formula: C20H18ClNO4
• Molecular Weight (g/mol): 371.817
• MDL Number: MFCD00011939
• InChI Key: VKJGBAJNNALVAV-UHFFFAOYSA-M
• Synonym: berberine chloride, berberine hydrochloride, natural yellow 18, benzodioxide, berberinium chloride, berberine hcl, unii-uot4o1byv8, berberine chloride jan, uot4o1byv8
• PubChem CID: 12456
• ChEBI: CHEBI:31271
• SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

• Color: Yellow to Orange
• Quantity: 5 g
• Beilstein: 3836585
• Solubility Information: Soluble in dimethyl sulfoxide (74mg/ml at 25°C),ethanol (<1mg/ml at 25°C),water (<1mg/ml at 25°C),and methanol.
• Formula Weight: 371.82
• Physical Form: Powder
• Chemical Name or Material: Berberine chloride

Safety and Handling

EINECSNumber	211-195-9
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only