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(±)-Blebbistatin, Tocris Bioscience™
GSA_VA

Catalog No. 176010R Shop All R&D Systems Products
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Selective inhibitor of myosin II ATPase activity

(±)-Blebbistatin is a selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (?)-Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. (?)-Blebbistatin inhibits arterial thrombosis development, reduces infiltration of inflammatory cells, and reduces damage to vascular tissue in vivo in a mice model of arterial thrombosis.

Active and Inactive Enantiomer also available.

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Chemical Identifiers

CAS 674289-55-5
Molecular Formula C18H16N2O2
Molecular Weight (g/mol) 292.338
InChI Key LZAXPYOBKSJSEX-UHFFFAOYSA-N
Synonym +/--blebbistatin, blebbistatin, 3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo 2,3-b quinolin-4-one, 3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4h-pyrrolo 2,3-b quinolin-4-one, +--blebbistatin, 3a-hydroxy-6-methyl-1-phenyl-2h,3h-pyrrolo 2,3-b quinolin-4-one, 1-phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo 2.3-b-7-methylquinolin-4-one, inverted exclamation marka-blebbistatin, +/-bebbistatin, --blebbistcitin
PubChem CID 3476986
ChEBI CHEBI:75379
IUPAC Name 3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
SMILES CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O

Specifications

Quantity 10 mg
Formula Weight 292.34
Percent Purity >98%
Chemical Name or Material (±)-Blebbistatin

Safety and Handling

Recommended Storage Store at +4°C
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