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Bumetanide, Tocris Bioscience™

Catalog No. 310850 Shop All R&D Systems Products
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Quantity:
50 mg
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This item is not returnable. View return policy

Description

Na+/2Cl-/K+ (NKCC) symporter inhibitor

Bumetanide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer's disease transcriptomic signatures.

Chemical Identifiers

CAS 28395-03-1
Molecular Formula C17H20N2O5S
Molecular Weight (g/mol) 364.416
InChI Key MAEIEVLCKWDQJH-UHFFFAOYSA-N
Synonym bumetanide, 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid, bumex, burinex, fordiuran, lunetoron, fontego, segurex, bumetanida, bumetanidum
PubChem CID 2471
ChEBI CHEBI:3213
IUPAC Name 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
SMILES CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2

Specifications

Quantity 50 mg
Formula Weight 364.42
Percent Purity 98%
Chemical Name or Material Bumetanide

Safety and Handling

Recommended Storage Store at Room Temperature
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