MilliporeSigma™ Calbiochem™ Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride

Description

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i =

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27nM). Exhibits reduced affinity for A_2B receptors (K_i = 67nM), but offers greater selectivity over A_1R (K_i = 290nM) and A_3R (88.8μM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Content And Storage: Protect from light
• Quantity: 5 mg
• Form: Solid
• Color: White
• Formulation: Supplied as a hydrochloride salt.
• Description: 98% by HPLC
• Molecular Formula: C₂₃H₂₉N₇O₆·HCl
• Formula Weight: 536g/mol
• Solubility: DMSO