MilliporeSigma™ Calbiochem™ Adenosine Receptor Agonist, NECA

Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_{i = 14 nM, 20 nM}

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_i = 14 nM, 20 nM, 2.4μM and 6.2nM for A₁, A_2A, A_2B, A₃, respectively). Increases intracellular cAMP production (EC₅₀ = 3.1μM in A_2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Specifications

• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg
• Color: White
• Description: 99% by HPLC
• Molecular Formula: C₁₂H₁₆N₆O₄
• Formula Weight: 308.3g/mol
• Solubility: DMSO