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MilliporeSigma™ Calbiochem™ Ras/Rac Transformation Blocker, SCH 51344

Catalog No. 55350910MG Shop All MilliporeSigma Products
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10mg

Description

Ras/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation and Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.

A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).

Specifications

Content And Storage Protect from light
Form Solid
Quantity 10 mg
Color Light Yellow
Description 98% by HPLC
Target Proteins Ras/Rac
CAS 171927-40-5
Molecular Formula C16H20N4O3
Formula Weight 316.4g/mol
Solubility DMSO
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