Calcium Channel beta-4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5110802

Catalog No. PIPA5110802

Description

Immunogen sequence: EHLGEYLEAY WRATHTTSST PMTPLLGRNL GSTALSPYPT AISGLQSQRM RHSNHSTENS PIERRSLMTS DENYHNERAR KSRNRLSSSS QHSRDHYPLV EEDYPDS

This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Calcium Channel beta-4
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O00305
• Gene Symbols: Cacnb4
• Immunogen: Recombinant Protein corresonding to Human Calcium Channel beta-4
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: Cacnb4
• Gene Alias: 3110038O15Rik; CAB4; Cacnb4; CACNLB4; calcium channel beta 4 subunit; calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; calcium voltage-gated channel auxiliary subunit beta 4; Cchb4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; EA5; EIG9; EJM; EJM4; EJM6; lh; OTTHUMP00000207247; OTTHUMP00000207249; Voltage-dependent L-type calcium channel subunit beta-4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 785
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid