Thermo Scientific Chemicals Calpain Inhibitor II, 95+%

An inhibitor of calpains I and II

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

CAS

136632-32-1

Molecular Formula

C₁₉H₃₅N₃O₄S, C19H35N3O4S

Synonym

N-Ac-Leu-Leu-Methioninal; ALLM

Quantity

25 mg

Description

White

Content And Storage

-30°C to -10°C

For Use With (Application)

An inhibitor of calpains I and II

Formula Weight

401.60g/mol

Solubility

Soluble in ethanol at 20mg/ml

Product Type

Signal Transduction Reagent

Form

Powder

Beilstein

7693643

InChI Key

RJWLAIMXRBDUMH-UHFFFAOYNA-N

SMILES

CSCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O

IUPAC Name

2-acetamido-4-methyl-N-(3-methyl-1-{[4-(methylsulfanyl)-1-oxobutan-2-yl]carbamoyl}butyl)pentanamide

Molecular Weight (g/mol)

401.57

Assay

≥95%

Recommended Storage

Store at -20°C

SDS

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only