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Calpeptin, Tocris Bioscience™

Catalog No. 044810 Shop All R&D Systems Products
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Calpain and cathepsin L inhibitor

Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases. Also inhibits SARS-CoV-2 Mpro in vitro (IC50 = 10.7 μM) and inhibits viral replication.

Chemical Identifiers

CAS

117591-20-5

Molecular Formula

C20H30N2O4

Molecular Weight (g/mol)

362.47

InChI Key

PGGUOGKHUUUWAF-ROUUACIJSA-N

Synonym

calpeptin, n-cbz-leu-nleu-al, benzylcarbonyl-leu-nleu-h, unii-18x9fr245w, chembl92708, n-benzyloxycarbonyl-l-leucylnorleucinal, carbamic acid, 1-1-formylpentyl amino carbonyl-3-methylbutyl-, phenylmethyl ester, s-r*,r*, benzyl n-1s-3-methyl-1-2s-1-oxohexan-2-yl carbamoyl butyl carbamate, carbamic acid, 1-1-formylpentyl amino carbonyl-3-methylbutyl-, phenylemthyl ester, s-r*,r*

PubChem CID

73364

ChEBI

CHEBI:3330

IUPAC Name

benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]carbamate

SMILES

CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

Specifications

Quantity

10 mg

Formula Weight

362.47

Percent Purity

>98%

Chemical Name or Material

Calpeptin

Recommended Storage

Desiccate at +4°C
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