CaMKII beta Mouse anti-Fish, Human, Mouse, Ovine, Rat, Sea urchin, Clone: CB-beta-1, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen 139800

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Catalog No. 13-980-0

Description

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Specifications

• Antigen: CaMKII beta
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P08413, P28652, Q13554
• Gene Symbols: CAMK2B
• Immunogen: Purified rat brain CaM Kinase.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Fish, Human, Mouse, Ovine, Rat, Sea urchin
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: CB-beta-1
• Conjugate: Unconjugated
• Gene: CAMK2B
• Gene Alias: Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II, beta; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; caM kinase II subunit beta; CAM2; CaMK II; CAMK2; CAMK2B; Camk2d; CAMKB; caMK-II subunit beta; caM-kinase II beta chain; Ck2b; hypothetical protein LOC525416; MGC29528; proline rich calmodulin-dependent protein kinase; β CaMKII; βCaMKII
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101118870, 12323, 24245, 816
• Content And Storage: -20°C
• Form: Liquid