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CCT 018159, Tocris Bioscience™

Catalog No. p-4783835 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Hsp90 inhibitor

Novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC50 = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (Cat. No. 1515) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

Chemical Identifiers

CAS 171009-07-7
Molecular Formula C20H20N2O4
Molecular Weight (g/mol) 352.39
InChI Key BBTMGPQSLSYPHE-UHFFFAOYSA-N
Synonym 6-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-methyl-1,2-dihydropyrazol-3-ylidene-4-ethyl-3-hydroxycyclohexa-2,4-dien-1-one, kinome_3591, owpmenvyxdjdow-uhfffaoysa-n, 4-4-2,3-dihydro-benzo 1,4 dioxin-6-yl-5-methyl-1h-pyrazol-3-yl-6-ethyl-benzene-1,3-diol
PubChem CID 6749166
IUPAC Name 6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-4-ethyl-3-hydroxycyclohexa-2,4-dien-1-one
SMILES CCC1=CC(=C2C(=C(NN2)C)C3=CC4=C(C=C3)OCCO4)C(=O)C=C1O

Specifications

Quantity 10 mg
Formula Weight 352.39
Percent Purity >98%
Chemical Name or Material CCT 018159

Safety and Handling

Recommended Storage Store at +4°C
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