Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
CD127 (IL-7 Receptor α) Mouse, anti-Human, RB780, Clone: HIL-7R-M21, BD Horizon™
Mouse Monoclonal Antibody
$168.70 - $363.50
Specifications
| Antigen | CD127 (IL-7 Receptor α) |
|---|---|
| Clone | HIL-7R-M21 |
| Applications | Flow Cytometry |
| Conjugate | RB780 |
| Host Species | Mouse |
Description
The hIL-7R-M21 monoclonal antibody specifically binds to the 60-90 kDa glycoprotein, CD127. CD127 is also known as the IL-7 receptor alpha (IL-7Rα) subunit. The IL-7 receptor complex is a heterodimer composed of CD127 and the common gamma chain (γc, CD132), shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, IL-15R, and IL-21R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 Receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high surface expression of CD25, the α chain of the IL-2 receptor complex, can distinguish between human regulatory and conventional CD4+ T cells in human adult and cord blood, lymph nodes and thymus.
Specifications
| CD127 (IL-7 Receptor α) | |
| Flow Cytometry | |
| Mouse | |
| Human | |
| 3575 | |
| IgG1 κ | |
| Refrigerate (2°C to 8°C) |
| HIL-7R-M21 | |
| RB780 | |
| RUO | |
| Aqueous buffered solution containing ≤0.09% sodium azide | |
| Human IL-7R Recombinant Protein | |
| Secondary |
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title