CD127 (IL-7 Receptor α) Mouse, anti-Human, RB780, Clone: HIL-7R-M21, BD Horizon™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB568751	BD Biosciences 568751	25 Tests
BDB568750	BD Biosciences 568750	100 Tests

Description

The hIL-7R-M21 monoclonal antibody specifically binds to the 60-90 kDa glycoprotein, CD127. CD127 is also known as the IL-7 receptor alpha (IL-7Rα) subunit. The IL-7 receptor complex is a heterodimer composed of CD127 and the common gamma chain (γc, CD132), shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, IL-15R, and IL-21R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 Receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high surface expression of CD25, the α chain of the IL-2 receptor complex, can distinguish between human regulatory and conventional CD4+ T cells in human adult and cord blood, lymph nodes and thymus.

Specifications

• Antigen: CD127 (IL-7 Receptor α)
• Applications: Flow Cytometry
• Host Species: Mouse
• Target Species: Human
• Gene ID (Entrez): 3575
• Isotype: IgG1 κ
• Content And Storage: Refrigerate (2°C to 8°C)

• Clone: HIL-7R-M21
• Conjugate: RB780
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide
• Immunogen: Human IL-7R Recombinant Protein
• Primary or Secondary: Secondary