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CD88 Mouse, anti-Mouse, R718, Clone: 20/70, BD OptiBuild™
Mouse Monoclonal Antibody
Supplier: BD Biosciences 752094
Description
The 20/70 monoclonal antibody specifically binds to CD88, which is also known as, Complement component 5a receptor 1 (C5ar1), C5a anaphylatoxin chemotactic receptor, or C5a receptor (C5aR). CD88 belongs to the rhodopsin family of seven-transmembrane G protein-coupled receptors and mediates its effects by binding to the complement activation product, C5a. CD88 is expressed on leucocytes including, neutrophils, monocytes, macrophages, and eosinophils. CD88 may also be expressed on alveolar epithelial cells, endothelial cells, neural stem cells, oligodendrocytes, and on parenchymal cells of lung, liver, kidney and heart. Binding of the proinflammatory C5a anaphylatoxin to CD88 results in G-protein coupling and intracellular signal transduction that mediates intracellular calcium release, chemotaxis, degranulation, cytokine production, and superoxide anion production. The 20/70 antibody can block binding of C5a to CD88 and thus inhibit its biological functions.
Specifications
CD88 | |
Monoclonal | |
R718 | |
50 μg | |
Primary | |
Refrigerate Upon Arrival |
Flow Cytometry | |
20/70 | |
Mouse | |
RUO | |
Mouse | |
Liquid |
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