cis-Aconitic anhydride, 98%, Thermo Scientific Chemicals

Description

cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).

Notes
Moisture sensitive. Incompatible with strong acids, strong oxidizing agents and strong bases. Store in a cool place.

Specifications

Chemical Identifiers

• CAS: 6318-55-4
• Molecular Formula: C6H4O5
• Molecular Weight (g/mol): 156.093
• MDL Number: MFCD00005524
• InChI Key: GVJRTUUUJYMTNQ-UHFFFAOYSA-N
• Synonym: cis-aconitic anhydride, aconitic anhydride, cis-aconitic acid anhydride, 3-furanacetic acid, 2,5-dihydro-2,5-dioxo, 2-2,5-dioxo-2,5-dihydrofuran-3-yl acetic acid, 2,5-dioxofuran-3-yl acetic acid, 2-2,5-dioxo-3-furyl acetic acid, 1-propene-1,2,3-tricarboxylic acid, cyclic 1,2-anhydride, 2,5-dioxo-2,5-dihydro-furan-3-yl-acetic acid, z-aconitic anhydride
• PubChem CID: 65163
• IUPAC Name: 2-(2,5-dioxofuran-3-yl)acetic acid
• SMILES: C1=C(C(=O)OC1=O)CC(=O)O

• Melting Point: 74°C to 78°C
• Quantity: 1 g
• UN Number: UN3261
• Beilstein: 127575
• Sensitivity: Moisture sensitive
• Formula Weight: 156.1
• Percent Purity: 98%
• Chemical Name or Material: cis-Aconitic anhydride

Safety and Handling

Hazard Category	H314-H335
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: III; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
EINECSNumber	228-663-3
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only