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Clozapine, Tocris Bioscience™

Catalog No. 0444500 Shop All R&D Systems Products
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Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively).

Chemical Identifiers

CAS

5786-21-0

Molecular Formula

C18H19ClN4

Molecular Weight (g/mol)

326.828

InChI Key

ZUXABONWMNSFBN-UHFFFAOYSA-N

Synonym

clozapine, leponex, clozapin, clozaril, fazaclo, clorazil, iprox, clozapinum, asaleptin, clozapina

PubChem CID

2818

IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

SMILES

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Specifications

Quantity

500 mg

Formula Weight

326.83

Percent Purity

>99%

Chemical Name or Material

Clozapine

Recommended Storage

Store at Room Temperature
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