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CNQX, Tocris Bioscience™

Catalog No. p-4783369 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Potent and selective non-NMDA iGluR antagonist

CNQX is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor-mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

CNQX Disodium Salt (Cat. No. 1045) also available.

Chemical Identifiers

CAS 115066-14-3
Molecular Formula C9H4N4O4
Molecular Weight (g/mol) 232.155
InChI Key RPXVIAFEQBNEAX-UHFFFAOYSA-N
Synonym cnqx, 6-cyano-7-nitroquinoxaline-2,3-dione, unii-6ote87sccw, 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, 6ote87sccw, 3h cnqx, 6-cyano-2,3-dihydroxy-7-nitroquinoxaline, 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile, 6-quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo, 2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile
PubChem CID 3721046
ChEBI CHEBI:34468
IUPAC Name 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
SMILES C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N

Specifications

Quantity 10 mg
Formula Weight 232.16
Percent Purity >99%
Chemical Name or Material CNQX

Safety and Handling

Recommended Storage Store at Room Temperature
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