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CP 100356 hydrochloride, Tocris Bioscience™

Catalog No. 419350 Shop All R&D Systems Products
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P-gp inhibitor

High affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC50 > 50 μM).

Chemical Identifiers

CAS

142715-48-8

Molecular Formula

C31H37ClN4O6

Molecular Weight (g/mol)

597.109

InChI Key

WWCHXVYTCMPAMV-UHFFFAOYSA-N

Synonym

cp 100356 hydrochloride, cp-100356 hydrochloride, cp-100356 monohydrochloride, 4-3,4-dihydro-6,7-dimethoxy-2 1h-isoquinolinyl-n-2-3,4-dimethoxyphenyl ethyl-6,7-dimethoxy-2-quinazolinamine monohydrochloride, cp-100356 monohydrochloride hplc, 4-3,4-dihydro-6,7-dimethoxy-2 1h-isoquinolinyl-n-2 2-3,4-dimethoxyphenyl ethyl-6,7-dimethoxy-2-quinazolinamine hydrochloride, 4-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl-n-2-3,4-dimethoxyphenyl ethyl-6,7-dimethoxyquinazolin-2-amine hydrochloride, 4-6,7-dimethoxy-3,4-dihydroisoquinolin-2 1h-yl-n-2-3,4-dimethoxyphenyl ethyl-6,7-dimethoxyquinazolin-2-amine-hydrogen chloride 1/1

PubChem CID

71312025

IUPAC Name

4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine;hydrochloride

SMILES

COC1=C(C=C(C=C1)CCNC2=NC3=CC(=C(C=C3C(=N2)N4CCC5=CC(=C(C=C5C4)OC)OC)OC)OC)OC.Cl

Specifications

Quantity

50 mg

Formula Weight

597.1

Percent Purity

>98%

Chemical Name or Material

CP 100356 hydrochloride

Recommended Storage

Desiccate at Room Temperature
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