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Tocris Bioscience™ CU-76

Catalog No. 78202 Shop All R&D Systems Products
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2 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.

Specifications

Chemical Name or Material Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate
CAS 2400954-58-5
Quantity 2 mg
Target STING/TMEM173
Molecular Formula C11H8F2IN5O2
Purity 0.98
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