Cyclopiazonic acid, 98%, Thermo Scientific Chemicals

Description

Inhibitor of the sarco/endoplasmic reticulum calcium pump, calcium-ATPase

The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.

Solubility
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (∼20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Keep in a dry place. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 18172-33-3
• Molecular Formula: C20H20N2O3
• Molecular Weight (g/mol): 336.391
• MDL Number: MFCD00167445
• InChI Key: SZINUGQCTHLQAZ-AFAVFJNCSA-N
• Synonym: cyclopiazonic acid, alpha-cyclopiazonic acid, unii-x9tly4580z, ccris 4942, alpha-cyclopiazonate, cyclopyazonic acid, 6ar,10z,11as,11br-10-1-hydroxyethylidene-7,7-dimethyl-6a,7,11a,11b-tetrahydro-6h-pyrrolo 1',2':2,3 isoindolo 4,5,6-cd indole-9,11 2h,10h-dione, 9h-pyrrolo 1',2':2,3 isoindolo 4,5,6-cd indol-9-one, 2,6,6a,7,11a,11b-hexahydro-10-acetyl-7,7-dimethyl-11-hydroxy-, 6a-alpha,11a,11b-alpha, 6ar,11as,11br-10-acetyl-9-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-11h-pyrrolo 1',2':2,3 isoindolo 4,5,6-cd indol-11-one, ambotzls-1020
• PubChem CID: 54711281
• SMILES: CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O

• Color: White
• Quantity: 50 mg
• UN Number: UN2811
• Solubility Information: Soluble in DMSO (100 mM),ethanol (5 mM),DMF (∽20mg/ml),and 1:1 DMSO:PBS(pH 7.2) (0.5mg/ml). Insoluble in water.
• Formula Weight: 336.39
• Percent Purity: ≥99%
• Physical Form: Powder
• Chemical Name or Material: Cyclopiazonic acid

Safety and Handling

Hazard Category	H300
Hazard Statement	GHS H Statement H300-H361 Fatal if swallowed. Suspected of damaging fertility or the unborn child.
Precautionary Statement	P264b-P270-P301+P310-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
RTECSNumber	UY8587000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only