DAPT, Thermo Scientific Chemicals

 

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth,

Chemical Identifiers

CAS

208255-80-5

Molecular Formula

C23H26F2N2O4

Molecular Weight (g/mol)

432.468

MDL Number

MFCD04974585

InChI Key

DWJXYEABWRJFSP-XOBRGWDASA-N

Synonym

dapt, dapt gsi-ix, gamma-secretase inhibitor ix, gsi-ix, insolution gamma-secretase inhibitor ix, s-tert-butyl 2-s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, n-n-3,5-difluorophenacetyl-l-alanyl-s-phenylglycine t-butyl ester, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetyl amino propanoyl amino-2-phenylacetate, gsiix

PubChem CID

5311272

ChEBI

CHEBI:86193

IUPAC Name

tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

SMILES

CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Color

White

Quantity

10 mg

Sensitivity

Light Sensitive

Solubility Information

Soluble in DMSO,ethanol,dichloromethane,DMF.

Formula Weight

432.5

Physical Form

Lyophilized

Chemical Name or Material

DAPT

TSCA

No

Recommended Storage

Store at -20°C; Store under Argon

SDS

TSCA

No

Recommended Storage

Store at -20°C; Store under Argon

SDS

RUO – Research Use Only