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Diclofenac sodium salt, Thermo Scientific Chemicals
Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Specifications
Melting Point
283°C to 285°C
Color
White
Quantity
5 g
UN Number
UN2811
Merck Index
14,3081
Solubility Information
Soluble in water to 50mg/ml.
Formula Weight
318.14
Physical Form
Powder
Chemical Name or Material
Diclofenac sodium salt
Hazard Category
H301
Hazard Statement
GHS H Statement
H301-H361
Toxic if swallowed.
Suspected of damaging fertility or the unborn child.
Precautionary Statement
P264b-P270-P301+P310-P330-P501c
DOTInformation
Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber
239-346-4
RTECSNumber
AG6330000
TSCA
No
Recommended Storage
Ambient temperatures
RUO – Research Use Only
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