Disulfiram, Tocris Bioscience™

Description

Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities

Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity. Pyroptosis inhibitor; binds gasdermin D (GSDMD) and inhibits pore formation. Also inhibits SARS-CoV-2 main protease (Mpro; IC50 = 9.35 μM) and inhibits viral replication in Vero cells in vitro.

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Specifications

Chemical Identifiers

• CAS: 97-77-8
• Molecular Formula: C10H20N2S4
• Molecular Weight (g/mol): 296.524
• InChI Key: AUZONCFQVSMFAP-UHFFFAOYSA-N
• Synonym: disulfiram, tetraethylthiuram disulfide, antabuse, alcophobin, antabus, anticol, bis diethylthiocarbamoyl disulfide, esperal, teturam, tetd
• PubChem CID: 3117
• ChEBI: CHEBI:4659
• IUPAC Name: diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
• SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC

• Quantity: 50 mg
• Formula Weight: 296.54
• Percent Purity: >98%
• Chemical Name or Material: Disulfiram

Safety and Handling

Recommended Storage

Store at +4°C