DL-Thioctic acid, 98%, Thermo Scientific Chemicals

Description

DL-Thioctic acid, CAS # 1077-28-7, is an antioxidant and coenzyme important for the activity of enzymes.

DL-Thioctic acid plays an essential role in aerobic metabolism. Further, it acts as a free radical scavenger.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• DL-Thioctic acid derives from octanoic acid, and it has been described as an antioxidant coenzyme important for the activity of enzyme complexes including pyruvate dehydrogenase and glycine decarboxylase

Application

• DL-Thioctic acid has been used in studies to increase insulin sensitivity and stimulate glucose uptake into adipose and muscle cells in vitro

• DL-Thioctic acid has an essential role in aerobic metabolism

• It has been used as free radical scavenger compound

• It can also assist in repairing oxidative damage via the increase of endogenous antioxidants, including vitamins C, vitamin E, and glutathione

• It can induce apoptosis through caspase-independent and caspase-dependent pathways, a process mediated by intracellular Ca2+

• DL-Thioctic acid has the ability to impact various cellular biological pathways since it can increase glutathione synthesis and modulate transcription factor activity, mainly nuclear factor kappa B (NF-κB)

• It can decrease the phagocytosis of myelin by macrophages

Specifications

Chemical Identifiers

• CAS: 1077-28-7
• Molecular Formula: C8H14O2S2
• Molecular Weight (g/mol): 206.32
• MDL Number: MFCD00005474
• InChI Key: AGBQKNBQESQNJD-UHFFFAOYNA-N
• Synonym: dl-thioctic acid, thioctic acid, alpha-lipoic acid, 5-1,2-dithiolan-3-yl pentanoic acid, dl-alpha-lipoic acid, 1,2-dithiolane-3-pentanoic acid, 6,8-thioctic acid, thioctacid, 6-thioctic acid, alpha lipoic acid
• PubChem CID: 864
• ChEBI: CHEBI:16494
• IUPAC Name: 5-(1,2-dithiolan-3-yl)pentanoic acid
• SMILES: OC(=O)CCCCC1CCSS1

• Melting Point: 59°C to 63°C
• Boiling Point: 160°C to 165°C
• Quantity: 5 g
• Beilstein: 81853
• Merck Index: 14,9326
• Solubility Information: Soluble in methanol,ethanol,diethyl ether and chloroform. Insoluble in water.
• Formula Weight: 206.33
• Percent Purity: 98%
• Chemical Name or Material: DL-Thioctic acid

Safety and Handling

Hazard Category	H302-H315-H319-H335
Hazard Statement	GHS H Statement H302-H315-H319-H335 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	214-071-2
RTECSNumber	JP1192000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only