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Docetaxel, 99%, Thermo Scientific Chemicals

Catalog No. AAJ60174ME
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Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities.

Docetaxel is a second-generation cytotoxic antimicrotubule agent and is mostly used in the pharmaceutical industry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death

Application

• Docetaxel can inhibit angiogenesis by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells

Chemical Identifiers

CAS

114977-28-5

Molecular Formula

C43H53NO14

Molecular Weight (g/mol)

807.89

MDL Number

MFCD00800737

InChI Key

ZDZOTLJHXYCWBA-VCVYQWHSSA-N

Synonym

docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl

PubChem CID

148124

ChEBI

CHEBI:4672

SMILES

CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

Specifications

Melting Point

186°C to 192°C

Color

White

Quantity

500 mg

Merck Index

14,3397

Solubility Information

Soluble in dimethyl sulfoxide and ethanol; Insoluble in water.

Formula Weight

807.88

Percent Purity

99%

Physical Form

Powder

Chemical Name or Material

Docetaxel

Hazard Category

H315-H319-H335-H361fd

Precautionary Statement

P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c

RTECSNumber

DA4172750

TSCA

No

Recommended Storage

Store at -20°C
SDS

RUO – Research Use Only

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