Dopamine beta Hydroxylase Polyclonal Antibody, Invitrogen™

Sheep Polyclonal Antibody

Supplier:  Thermo Scientific PA3925

Catalog No. PA3-925

Description

PA3-925 detects human, bovine, rat and mouse DBH. This antibody is not effective for immunohistochemistry in human brain. PA3-925 has been successfully used in Western blot, immunohistochemistry and immunofluorescence procedures. By Western blot, this antibody detects an ∽72 kDa protein representing DBH from rat neurons. In immunohistochemistry and immunofluorescence procedures, it specifically stains chromaffin cells of the adrenal medulla, and DBH containing cells of the sympathetic nervous system. The PA3-925 immunogen is a synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH. This sequence is highly conserved (>85% homology) in human, bovine and mouse.

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.

Specifications

• Antigen: Dopamine beta Hydroxylase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DBH
• Gene Alias: Dbh; DBM; dopamine beta hydroxylase; Dopamine beta hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase precursor; dopamine beta-hydroxylase precursor (EC 1.14.17.1); dopamine beta-monooxygenase; dopamine beta-monooxygenase precursor (EC 1.14.17.1); Dopamine-Beta-hydroxylase; DOPBHY; mixed function oxidase; Soluble dopamine beta-hydroxylase
• Host Species: Sheep
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with 0.05% sodium azide
• Gene Accession No.: P09172, P15101, Q05754, Q64237
• Gene Symbols: DBH
• Immunogen: Synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH.
• Regulatory Status: RUO
• Gene ID (Entrez): 13166, 1621, 25699, 280758
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid