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Eurofins Discoverx ChemiScreen D5 Dopamine Receptor Stable Cell Line, 2 vials. (HTS129C)
Supplier: Eurofins Discoverx HTS129C
The ChemiScreen D5 Dopamine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine) based activation of DRD5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses DRD5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of DRD5, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
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