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EHT 1864, Tocris Bioscience™

Catalog No. 387250 Shop All R&D Systems Products
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Potent Rac family inhibitor

Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo.

Chemical Identifiers

CAS

754240-09-0

Molecular Formula

C25H29Cl2F3N2O4S

Molecular Weight (g/mol)

581.472

InChI Key

LSECOAJFCKFQJG-UHFFFAOYSA-N

Synonym

5-5-7-trifluoromethyl quinolin-4-ylthio pentyloxy-2-morpholinomethyl-4h-pyran-4-one dihydrochloride, 2-morpholin-4-ylmethyl-5-5-7-trifluoromethyl quinolin-4-yl sulfanylpentoxy pyran-4-one;dihydrochloride, 4h-pyran-4-one,2-4-morpholinylmethyl-5-5-7-trifluoromethyl-4-quinolinyl thio pentyl oxy-,hydrochloride 1:2, d0m9er, eht 1864 2hcl, c25h27f3n2o4s.2clh, eht hplc, 2-morpholin-4-ylmethyl-5-5-7-trifluoromethyl quinolin-4-yl sulfanyl pentyl oxy pyran-4-one dihydrochloride, 2-morpholinomethyl-5-5-7-trifluoromethyl quinolin-4-yl thio pentyl oxy-4h-pyran-4-one dihydrochloride, 2-morpholin-4-yl methyl-5-5-7-trifluoromethyl quinolin-4-yl sulfanyl pentyl oxy-4h-pyran-4-one dihydrochloride

PubChem CID

9938202

IUPAC Name

2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one;dihydrochloride

SMILES

C1COCCN1CC2=CC(=O)C(=CO2)OCCCCCSC3=C4C=CC(=CC4=NC=C3)C(F)(F)F.Cl.Cl

Specifications

Quantity

50 mg

Formula Weight

581.47

Percent Purity

>98%

Physical Form

Solid

Chemical Name or Material

Rho GTPase Inhibitors

Recommended Storage

Store at +4°C
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