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TARGETMOL CHEMICALS INC EMEDASTINE 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Emedastine (LY188695) is a second generation selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins or by producing an anti-platelet activating factor effect. Upon ocular administration emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic dopamine or serotonin receptors. purity: 97%
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