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  5. Tocris Bioscience™ EPPTB

Tocris Bioscience™ EPPTB

Catalog No. p-7110774 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Trace amine 1 (TA1) receptor antagonist/inverse agonist

EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

Specifications

Chemical Name or Material N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
CAS 1110781-88-8
Quantity 50 mg
Target Trace Amine 1 (TA1) Receptor Antagonists
Molecular Formula C20H21F3N2O2
Formula Weight 378.39
Purity >99%
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