Thermo Scientific Chemicals β-Estradiol, 98%

β-Estradiol, 98%, CAS # 50-28-2, is an estrogen steroid sex hormone that regulates several biological functions including gene transcription and protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• β-Estradiol is a naturally occurring endogenous hormone in females

• It is an important steroid sex hormone involved in the regulation of several biological functions including gene transcription and protein synthesis

• This hormone is produced by the ovaries and can bind to and activate specific nuclear receptors

Applications

• β-Estradiol acts as an estrogenic hormone receptor agonist and activator of PI 3-kinase

• It shows inhibitory activity against aldehyde oxidase

• β-Estradiol presents mild anabolic and metabolic activities and increases blood coagulability in vivo experiments

• It plays a role in immune and inflammatory processes

• β-Estradiol triggers an increase in hepatic synthesis of some proteins, including sex hormone-binding globulin (SHBG), and thyroid-binding globulin (TBG), and suppresses the formation of follicle-stimulating hormone (FSH)

• This compound has been used for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)

Chemical Identifiers

CAS

50-28-2

Molecular Formula

C₁₈H₂₄O₂

Molecular Weight (g/mol)

272.38

InChI Key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Synonym

estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin

PubChem CID

5757

ChEBI

CHEBI:16469

IUPAC Name

(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

SMILES

CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

CAS Min %

97.5

CAS Max %

100.0

Melting Point

176.0°C to 180.0°C

Color

White

Infrared Spectrum

Authentic

Assay Percent Range

97.5% min. (HPLC)

Packaging

Glass bottle

Quantity

5 g

Merck Index

15,3758

Specific Rotation

+76° to +83° (20°C, 589nm) (c=1, dioxane)

Solubility Information

Solubility in water: insoluble. Other solubilities: soluble in chloroform, hexane, ethyl acetate

Formula Weight

272.38

Percent Purity

98%

Physical Form

Powder

Chemical Name or Material

β-Estradiol

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement
May cause cancer.
May cause damage to organs through prolonged or repeated exposure.
Suspected of damaging fertility.
Suspected of damaging the unborn child.
May cause harm to breast-fed children.

Precautionary Statement

GHS P Statement
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Use personal protective equipment as required.
IF exposed or concerned: Get medical advice/attention.

EINECSNumber

200-023-8

SDS

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement
May cause cancer.
May cause damage to organs through prolonged or repeated exposure.
Suspected of damaging fertility.
Suspected of damaging the unborn child.
May cause harm to breast-fed children.

Precautionary Statement

GHS P Statement
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Use personal protective equipment as required.
IF exposed or concerned: Get medical advice/attention.

EINECSNumber

200-023-8

SDS

RUO – Research Use Only