Thermo Scientific Chemicals β-Estradiol, 98%

Description

β-Estradiol, 98%, CAS # 50-28-2, is an estrogen steroid sex hormone that regulates several biological functions including gene transcription and protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• β-Estradiol is a naturally occurring endogenous hormone in females

• It is an important steroid sex hormone involved in the regulation of several biological functions including gene transcription and protein synthesis

• This hormone is produced by the ovaries and can bind to and activate specific nuclear receptors

Applications

• β-Estradiol acts as an estrogenic hormone receptor agonist and activator of PI 3-kinase

• It shows inhibitory activity against aldehyde oxidase

• β-Estradiol presents mild anabolic and metabolic activities and increases blood coagulability in vivo experiments

• It plays a role in immune and inflammatory processes

• β-Estradiol triggers an increase in hepatic synthesis of some proteins, including sex hormone-binding globulin (SHBG), and thyroid-binding globulin (TBG), and suppresses the formation of follicle-stimulating hormone (FSH)

• This compound has been used for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)

Specifications

Chemical Identifiers

• CAS: 50-28-2
• Molecular Formula: C₁₈H₂₄O₂
• Molecular Weight (g/mol): 272.38
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• PubChem CID: 5757
• ChEBI: CHEBI:16469
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

• CAS Min %: 97.5
• CAS Max %: 100.0
• Melting Point: 176.0°C to 180.0°C
• Color: White
• Infrared Spectrum: Authentic
• Assay Percent Range: 97.5% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 5 g
• Merck Index: 15,3758
• Specific Rotation: +76° to +83° (20°C, 589nm) (c=1, dioxane)
• Solubility Information: Solubility in water: insoluble. Other solubilities: soluble in chloroform, hexane, ethyl acetate
• Formula Weight: 272.38
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: β-Estradiol

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement May cause cancer. May cause damage to organs through prolonged or repeated exposure. Suspected of damaging fertility. Suspected of damaging the unborn child. May cause harm to breast-fed children.
Precautionary Statement	GHS P Statement Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention.
EINECSNumber	200-023-8

SDS

RUO – Research Use Only