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Fenobam, Tocris Bioscience™

Catalog No. 238650 Shop All R&D Systems Products
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Potent and selective mGlu5 negative allosteric modulator (NAM)

Potent and selective non-competitive mGlu5 negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo; also exhibits analgesic properties.

Chemical Identifiers

CAS

57653-26-6

Molecular Formula

C11H11ClN4O2

Molecular Weight (g/mol)

266.69

MDL Number

MFCD00868019

InChI Key

DWPQODZAOSWNHB-UHFFFAOYSA-N

Synonym

fenobam, fenobamum, fenobamum inn-latin, 3h fenobam, unii-078rcy7i27, 1-3-chlorophenyl-3-2e-1-methyl-4-oxoimidazolidin-2-ylidene urea, n-3-chlorophenyl-n'-4,5-dihydro-1-methyl-4-oxo-1h-imidazol-2-yl urea, dsstox_cid_26770, dsstox_rid_81892, dsstox_gsid_46770

PubChem CID

162834

IUPAC Name

1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea

SMILES

CN1CC(=O)N=C1NC(=O)NC1=CC=CC(Cl)=C1

Specifications

Quantity

50 mg

Formula Weight

266.69

Percent Purity

>99%

Chemical Name or Material

Fenobam

Recommended Storage

Store at Room Temperature
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