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Fenobam, Tocris Bioscience™

Catalog No. p-4783953 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Potent and selective mGlu5 negative allosteric modulator (NAM)

Potent and selective non-competitive mGlu5 negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo; also exhibits analgesic properties.

Chemical Identifiers

CAS 57653-26-6
Molecular Formula C11H11ClN4O2
Molecular Weight (g/mol) 266.69
MDL Number MFCD00868019
InChI Key DWPQODZAOSWNHB-UHFFFAOYSA-N
Synonym fenobam, fenobamum, fenobamum inn-latin, 3h fenobam, unii-078rcy7i27, 1-3-chlorophenyl-3-2e-1-methyl-4-oxoimidazolidin-2-ylidene urea, n-3-chlorophenyl-n'-4,5-dihydro-1-methyl-4-oxo-1h-imidazol-2-yl urea, dsstox_cid_26770, dsstox_rid_81892, dsstox_gsid_46770
PubChem CID 162834
IUPAC Name 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
SMILES CN1CC(=O)N=C1NC(=O)NC1=CC=CC(Cl)=C1

Specifications

Quantity 10 mg
Formula Weight 266.69
Percent Purity >99%
Chemical Name or Material Fenobam

Safety and Handling

Recommended Storage Store at Room Temperature
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