Fumonisin B1, 96%, Thermo Scientific Chemicals

Fumonisin, CAS # 116355-83-0, also known as Macrofusine, is a cell permeable mycotoxin that is an inhibitor of sphingosine N-acetyl transferase.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fumonisin is a fungal metabolite that is a cell permeable mycotoxin that can halt sphingolipid biosynthesis by inhibiting sphingosine N-acetyl transferase

Applications

• It can potently inhibit sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases

• It is also a protein serine and threonine phosphatase inhibitor

• It can selectively inhibit sphingomyelin biosynthesis in neuronal cells

Chemical Identifiers

CAS

116355-83-0

Molecular Formula

C₃₄H₅₉NO₁₅

Molecular Weight (g/mol)

721.8

MDL Number

MFCD00133349

InChI Key

UVBUBMSSQKOIBE-UWCNXKJPSA-N

Synonym

macrofusine, fumonisin b1, 2r,2'r-1,2,3-propanetricarboxylic acid 1,1'-1s,2r-1-2s,4r,9r,11s,12s-12-amino-4,9,11-trihydroxy-2-methyltridecyl-2-1r-1-methylpentyl-1,2-ethanediyl ester, 2s-2-2-5r,6r,7s,9s,11r,16r,18s,19s-19-amino-6-3r-3,4-dicarboxybutanoyl oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl oxy-2-oxoethyl butanedioic acid

PubChem CID

16760030

IUPAC Name

(2S)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid

SMILES

CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O

Color

Tan to White

Elemental Analysis

55.00 to 58.00%C, 1.60 to 2.20%N

Assay Percent Range

95% min. (HPLC)

Quantity

5 mg

Merck Index

15, 4318

Solubility Information

Solubility in water: soluble. Other solubilities: soluble in methanol,acetonitrile

Formula Weight

721.8

Percent Purity

96%

Physical Form

Powder

Chemical Name or Material

Fumonisin B1

Hazard Category

GHS Signal Word: Warning

Hazard Statement

GHS H Statement:
Suspected of causing cancer.

Precautionary Statement

GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

SDS

Hazard Category

GHS Signal Word: Warning

Hazard Statement

GHS H Statement:
Suspected of causing cancer.

Precautionary Statement

GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

SDS

RUO – Research Use Only