Fumonisin B2, 96+%, Thermo Scientific Chemicals

Description

Fumonisin B2, CAS # 116355-84-1, is a diester of tricarballylic acid and is isolated from Fusarium.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fumonisin B2 is a fumonisin mycotoxin produced by the fungus Fusarium

• Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than B1 and can inhibit sphinganine-N-acetyltransferase (ceramide synthase)

Applications

• In vitro and in vivo studies have shown Fumonisin B2 can induce apoptosis

• It can inhibit de novo sphingolipid biosynthesis

• It is also considered an Aspergillus metabolite

• It shows cytotoxicity against a panel of seven rat hepatoma cell lines, and MDCK cell line

• It induces hepatocyte nodule formation, a marker of cancer initiation, in rats

Specifications

Chemical Identifiers

• CAS: 116355-84-1
• Molecular Formula: C₃₄H₅₉NO₁₄·₃H₂O
• Molecular Weight (g/mol): 759.9
• InChI Key: UXDPXZQHTDAXOZ-FWPUDPCBSA-N
• Synonym: fumonisin b2, 2r,2'r-1,2,3-propanetricarboxylic acid 1,1'-1s,2r-1-2s,9r,11s,12s-12-amino-4,9,11-trihydroxy-2-methyltridecyl-2-1r-1-methylpentyl-1,2-ethanediyl ester, 2s-2-2-5r,6r,7s,9s,16r,18s,19s-19-amino-6-3r-3,4-dicarboxybutanoyl oxy-16,18-dihydroxy-5,9-dimethylicosan-7-yl oxy-2-oxoethyl butanedioic acid
• PubChem CID: 71317007
• IUPAC Name: (2S)-2-[2-[(5R,6R,7S,9S,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-16,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid
• SMILES: CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O

• Assay Percent Range: 96+%
• Quantity: 1 mg
• Solubility Information: Solubility in water: .. Other solubilities: soluble in methanol
• Formula Weight: 759.9
• Percent Purity: 96+%
• Chemical Name or Material: Fumonisin B2

Safety and Handling

Hazard Category

GHS Signal Word: Danger

SDS

RUO – Research Use Only