Fumonisin B2, 96+%, Thermo Scientific Chemicals

Fumonisin B2, CAS # 116355-84-1, is a diester of tricarballylic acid and is isolated from Fusarium.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fumonisin B2 is a fumonisin mycotoxin produced by the fungus Fusarium

• Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than B1 and can inhibit sphinganine-N-acetyltransferase (ceramide synthase)

Applications

• In vitro and in vivo studies have shown Fumonisin B2 can induce apoptosis

• It can inhibit de novo sphingolipid biosynthesis

• It is also considered an Aspergillus metabolite

• It shows cytotoxicity against a panel of seven rat hepatoma cell lines, and MDCK cell line

• It induces hepatocyte nodule formation, a marker of cancer initiation, in rats

Chemical Identifiers

CAS

116355-84-1

Molecular Formula

C₃₄H₅₉NO₁₄·₃H₂O

Molecular Weight (g/mol)

759.9

InChI Key

UXDPXZQHTDAXOZ-FWPUDPCBSA-N

Synonym

fumonisin b2, 2r,2'r-1,2,3-propanetricarboxylic acid 1,1'-1s,2r-1-2s,9r,11s,12s-12-amino-4,9,11-trihydroxy-2-methyltridecyl-2-1r-1-methylpentyl-1,2-ethanediyl ester, 2s-2-2-5r,6r,7s,9s,16r,18s,19s-19-amino-6-3r-3,4-dicarboxybutanoyl oxy-16,18-dihydroxy-5,9-dimethylicosan-7-yl oxy-2-oxoethyl butanedioic acid

PubChem CID

71317007

IUPAC Name

(2S)-2-[2-[(5R,6R,7S,9S,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-16,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid

SMILES

CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O

Assay Percent Range

96+%

Quantity

1 mg

Solubility Information

Solubility in water: .. Other solubilities: soluble in methanol

Formula Weight

759.9

Percent Purity

96+%

Chemical Name or Material

Fumonisin B2

Hazard Category

GHS Signal Word: Danger

SDS

Hazard Category

GHS Signal Word: Danger

SDS

RUO – Research Use Only