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GDC 0879, Tocris Bioscience™

Catalog No. p-4816999 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Potent B-Raf inhibitor

Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.

Chemical Identifiers

CAS 905281-76-7
Molecular Formula C19H18N4O2
Molecular Weight (g/mol) 334.379
InChI Key DEZZLWQELQORIU-UHFFFAOYSA-N
Synonym e-5-1-2-hydroxyethyl-3-pyridin-4-yl-1h-pyrazol-4-yl-2,3-dihydroinden-1-one oxime, 2-4-1-hydroxyimino-2,3-dihydroinden-5-yl-3-pyridin-4-yl pyrazol-1-yl ethanol, 5-1-2-hydroxyethyl-3-pyridin-4-yl-1h-pyrazol-4-yl-2,3-dihydroinden-1-one oxime
PubChem CID 57519545
IUPAC Name 2-[4-(1-hydroxyimino-2,3-dihydroinden-5-yl)-3-pyridin-4-ylpyrazol-1-yl]ethanol
SMILES C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

Specifications

Quantity 10 mg
Formula Weight 334.37
Percent Purity >98%
Chemical Name or Material GDC 0879

Safety and Handling

Recommended Storage Store at -20°C
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