Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Biochemical Reagents
  4. Nucleosides and Analogues
  5. Pyrimidine nucleosides
  6. Gemcitabine hydrochloride, Tocris Bioscience™

Gemcitabine hydrochloride, Tocris Bioscience™

Catalog No. p-4783983 Shop All R&D Systems Products
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

DNA synthesis inhibitor

Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.

Chemical Identifiers

CAS 122111-03-9
Molecular Formula C9H12ClF2N3O4
Molecular Weight (g/mol) 299.659
InChI Key OKKDEIYWILRZIA-OSZBKLCCSA-N
Synonym gemcitabine hcl, 2',2'-difluorodeoxycytidine monohydrochloride, 2'-deoxy-2',2'-difluorocytidine hydrochloride, 2 1h-pyrimidinone, 4-amino-1-2-deoxy-2,2-difluoro-d-erythro-pentofuranosyl
PubChem CID 44558863
ChEBI CHEBI:31647
IUPAC Name 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydron;chloride
SMILES [H+].C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.[Cl-]

Specifications

Quantity 10 mg
Formula Weight 299.66
Percent Purity >99%
Chemical Name or Material Gemcitabine hydrochloride

Safety and Handling

Recommended Storage Desiccate at +4°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.