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Genistein, Tocris Bioscience™

Catalog No. p-4783479 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ42 and amylin37 (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

Chemical Identifiers

CAS 446-72-0
Molecular Formula C15H10O5
Molecular Weight (g/mol) 270.24
MDL Number MFCD00016952
InChI Key TZBJGXHYKVUXJN-UHFFFAOYSA-N
Synonym genistein, prunetol, genisteol, 4',5,7-trihydroxyisoflavone, genisterin, sophoricol, 5,7,4'-trihydroxyisoflavone, bonistein, 5,7-dihydroxy-3-4-hydroxyphenyl-4h-chromen-4-one, genestein
PubChem CID 5280961
ChEBI CHEBI:28088
IUPAC Name 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
SMILES OC1=CC=C(C=C1)C1=COC2=CC(O)=CC(O)=C2C1=O

Specifications

Quantity 10 mg
Formula Weight 270.24
Percent Purity >98%
Chemical Name or Material Genistein

Safety and Handling

Recommended Storage Desiccate at -20°C
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