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GF 109203X, Tocris Bioscience™

Catalog No. p-4783480 Shop All R&D Systems Products
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Quantity:
1 mg
10 mg
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This item is not returnable. View return policy

Description

Protein kinase C inhibitor

Very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo.

Chemical Identifiers

CAS 133052-90-1
Molecular Formula C25H24N4O2
Molecular Weight (g/mol) 412.493
InChI Key QMGUOJYZJKLOLH-UHFFFAOYSA-N
Synonym bisindolylmaleimide i, unii-l79h6n0v6c, rbt205 inhibitor, gö 6850, bisindolylmaleimide i gf 109203x, bim-1, chembl7463, 2-1-3-dimethylaminopropyl indol-3-yl-3-indol-3-yl maleimide, 3-1-3-dimethylamino propyl-1h-indol-3-yl-4-1h-indol-3-yl-1h-pyrrole-2,5-dione
PubChem CID 2396
ChEBI CHEBI:41072
IUPAC Name 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
SMILES CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Specifications

Quantity 1 mg
Formula Weight 412.49
Percent Purity >98%
Chemical Name or Material GF 109203X

Safety and Handling

Recommended Storage Store at Room Temperature
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