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  8. 39951

GI 254023X, Tocris Bioscience™

Catalog No. 39951 Shop All R&D Systems Products
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

Selective ADAM10 metalloprotease inhibitor

Selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Blocks constitutive release of IL-6R, CX3CL1 and CXCL16 in cell-based cleavage experiments. Inhibits calcium ionophore-induced betacellulin shedding in IMPE cells. Prevents E-cadherin cleavage in A549 cells. Inhibits ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro.

Chemical Identifiers

CAS 260264-93-5
Molecular Formula C21H33N3O4
Molecular Weight (g/mol) 391.51
MDL Number MFCD19381832
InChI Key GHVMTHKJUAOZJP-UHFFFAOYNA-N
Synonym 2r-n-1s-2,2-dimethyl-1-methylamino carbonyl propyl-2-1s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, 2r,3s-3-formylhydroxyamino-2-3-phenyl-1-propyl butanoic acid 1s-2,2-dimethyl-1-methylcarbamoyl-1-propyl amide, bidd:pxr0042, gi254023x hplc, 2r-n-1s-2,2-dimethyl-1-methylcarbamoyl propyl-2-1s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, 2r-n-2s-3,3-dimethyl-1-methylamino-1-oxidanylidene-butan-2-yl-2-1s-1-methanoyl oxidanyl amino ethyl-5-phenyl-pentanamide, 2r-n-2s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-1s-1-formyl hydroxy amino ethyl-5-phenylpentanamide, r-n-s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, gi 254023x r-n-s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-s-1-nhydroxyformamido
PubChem CID 9952396
IUPAC Name N-[2,2-dimethyl-1-(methylcarbamoyl)propyl]-2-[1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide
SMILES CNC(=O)C(NC(=O)C(CCCC1=CC=CC=C1)C(C)N(O)C=O)C(C)(C)C

Specifications

Quantity 1 mg
Formula Weight 391.5
Percent Purity >98%
Chemical Name or Material GI 254023X

Safety and Handling

Recommended Storage Store at -20°C
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