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Glibenclamide, Tocris Bioscience™

Catalog No. 0911100 Shop All R&D Systems Products
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Kir6 (KATP) channel blocker

ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Chemical Identifiers

CAS

10238-21-8

Molecular Formula

C23H28ClN3O5S

Molecular Weight (g/mol)

494.003

InChI Key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Synonym

glyburide, glibenclamide, glybenclamide, micronase, diabeta, glynase, daonil, euglucon, maninil, semi-daonil

PubChem CID

3488

ChEBI

CHEBI:5441

IUPAC Name

5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide

SMILES

COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Specifications

Quantity

100 mg

Formula Weight

494

Percent Purity

>99%

Chemical Name or Material

Glibenclamide

Recommended Storage

Store at Room Temperature
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