GR 127935 hydrochloride, Tocris Bioscience™

Description

Potent and selective 5-HT1B and 5-HT1D antagonist

Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.

Specifications

Chemical Identifiers

• CAS: 148642-42-6
• Molecular Formula: C29H32ClN5O3
• Molecular Weight (g/mol): 534.057
• InChI Key: SRVVUYIJVBLEJI-UHFFFAOYSA-N
• PubChem CID: 11497466
• ChEBI: CHEBI:64111
• IUPAC Name: N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride
• SMILES: CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C.Cl

• Quantity: 10 mg
• Synonym: gr 127935 hydrochloride, gr127935 hydrochloride, gr 127935 hydrochloride hydrate, n-4-methoxy-3-4-methyl-1-piperazinyl phenyl-2'-methyl-4'-5-methyl-1,2,4-oxadiazol-3-yl-1,1'-biphenyl-4-carboxamide hydrochloride, n-4-methoxy-3-4-methylpiperazin-1-yl phenyl-2'-methyl-4'-5-methyl-1,2,4-oxadiazol-3-yl biphenyl-4-carboxamide hydrochloride, 4-2-methoxy-5-2'-methyl-4'-5-methyl-1,2,4-oxadiazol-3-yl biphenyl-4-yl carbonyl amino phenyl-1-methylpiperazin-1-ium chloride
• Formula Weight: 534.06
• Percent Purity: >99%
• Chemical Name or Material: GR 127935 hydrochloride

Safety and Handling

Recommended Storage

Desiccate at Room Temperature