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  5. Tocris Bioscience™ GSK 1702934A

Tocris Bioscience™ GSK 1702934A

Catalog No. p-7161627 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective TRPC3/6 activator

GSK 1702934A is a potent and selective TRPC3/6 activator (EC50 = 80 and 440 nM for TRPC3 and 6, respectively). Exhibits no activity at TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations <10 μmol/L. Induces TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6. Directly activates TRPC channels through by-passing phospholipase-C signaling. Also induces calcium signals in HEK-TRPC6 cells (pEC50 = 6.6).

Specifications

Chemical Name or Material 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
CAS 924377-85-5
Quantity 10 mg
Molecular Formula C22H25N3O2S
Formula Weight 395.52
Purity 98%
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